Jessie  Zhao

Jessie Zhao

Scholar Title

MIT ChemE Undergraduate Research and Innovation Scholar

Research Title

Structural Determinants of Antibody Nonspecificity

Cohort

2016–2017

Department

Chemical Engineering

Research Areas
  • Biological and Medical Devices and Systems
Supervisor

Wittrup

Abstract

As in vitro immune repertoires derived from display systems have grown increasingly popular as an alternative method to isolating antibodies there is greater need for improved screening methods to select for antibodies that have favorable developability profiles and select against antibodies that show signs of aggregation poor stability and nonspecificity. This project aims to develop an early-stage platform combining yeast surface display and antibody library design that can detect and correlate upstream nonspecificity to downstream developability of antibodies in order to improve the late-stage success of monoclonal antibody therapeutics developed from display platforms.

Quote

Through SuperUROP I intend to explore protein engineering and biotherapeutic design in understanding antibody nonspecificity.

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