Spectroscopy is a method of studying objects or materials based on their color. The pattern of color emitted or reflected by the object contains information about the underlying chemical components that make up the object. Broadband methods like multispectral imaging may lack the specificity to uniquely identify and distinguish species. For many species, this ambiguity can be resolved by measuring Raman scattering, which exhibits sharp, distinct ‘chemical fingerprints’ for the molecular components. A novel hyperspectral chemical imaging approach, Swept Source Wide-Field Raman Imaging (SSRI), employs a tunable laser and silicon based 2D pixel array. This technique enables wide-field chemical imaging without the need for point-by-point scanning or bulky spectrometers, making it more adaptable to large-scale applications. While the existing prototype SSRI instrument has achieved remarkable performance, the goal is to develop a portable system with an even wider field of view and better sensitivity. In this project, we will model and optimize the optical path for the camera lens of the SSRI system utilizing software for optical system design. The lens will then be constructed to maximize light collection while maintaining image fidelity across the operating range. After construction of this optimized lens system, we will demonstrate the performance of the SSRI system on a range of biological tissue samples. Of particular interest are tissue samples relevant for rapid assessment of tumor margins for resection of soft-tissue sarcoma, which has previously been tested clinically with conventional Raman imaging tools and would benefit from the performance improvements of SSRI.

I look forward to participating in the SuperUROP program in order to further develop my research and communication skills. My previous UROP project and classes including 8.04 (Quantum Physics I) and 6.3000 (Signal Processing) have fueled my interest in optics, photonics, and imaging. I am excited to take on the challenge of developing this new optical system. Furthermore, I am eager to design and construct a system that has potential for impact in the fields of biology and medicine.