Phuong Mai Pham

Phuong Mai Pham
MIT EECS | Landsman Undergraduate Research and Innovation Scholar
Advisor: Manolis Kellis
Department: EECS
Areas of Research: Computational Biology
Years: 2018-2019
Research Project Title:

Blood-Based Markers of Response to Immunotherapy in Melanoma

abstract:Despite cancer research development, sustained investment, and new medical advances, cancer is still one of the two major causes of death in the United States. Although immunotherapy has delivered promising results, only a fraction of patients receives long-term clinical benefits from it. Our research focuses on cancer checkpoint blockade immunotherapy for patients with melanoma, one of the most common cancer types in the U.S. Previous studies have shown correlative markers of checkpoint blockade therapy success and identified several potential mechanisms of immune escape but the clinical utility of these findings is still unclear. We hypothesize that the success of immunotherapy is based on a complex combination of factors in both tumor and immune components of the tumor microenvironment.

Through the SuperUROP program, I want to apply my background in computer and data science, and molecular biology in conducting independent research. I hope to broaden my knowledge in the science of cancer and I am excited to contribute to the development of cancer research.