Luzdary  Ruelas

Luzdary Ruelas

Scholar Title

MIT ChemE Undergraduate Research and Innovation Scholar

Research Title

Crystallization of Diphenhydramine using Functionalized Iron Oxide Nanoparticles




Chemical Engineering


Allan Myerson


Alternative Antisolvent Crystallization of Diphenhydramine with Functionalized Iron Oxide Nanoparticle
The global shift towards sustainable technology has motivated research for waste minimization in chemical processes such as crystallization. Crystallization is used to form a pure crystal from a saturated solution. Currently antisolvent crystallization is the most widely used technique but it fails to meet green chemistry specifications by adding more solvent to the original solution ultimately increasing waste. Using functionalized iron oxide nanoparticles as an alternative to antisolvent crystallization addresses waste problems since the particles have magnetic and tunable properties making separation easier and allowing their reuse. My SuperUROP project will focus on developing a crystallization and purification method for a diphenhydramine system using functionalized nanoparticles.


SuperUROP allows me to drive the work and lets me devote myself to research. My project is to change the solubility of diphenhydramine in solvents by adding functionalized iron oxide nanoparticles. My background provides insight for beginning but crystallization is new to me so I hope to learn more about the field. This project excites me because it addresses issues from environmental factors to the manufacture of drugs.

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