Julia Van Cleef

Julia  Van Cleef
MIT ChemE | Pall Biotech Research and Innovation Scholar
Advisor: Katie Galloway
Department: ChemE
Areas of Research: Biological Engineering
Years: 2021-2022
Research Project Title:

Implementing a Dual-Color MicroRNA Based Reporting System for Cellular Reprogramming

abstract:Based on current research, it can be said that past attempts at cellular reprogramming have been relatively inefficient. The goal of this project will be to implement a dual-color microRNA based reporting system that can be used in cellular reprogramming. Specifically, I will focus on improving reprogramming efficiency by introducing additional circuit elements and testing the circuits in a reprogramming context. In addition, I will examine the temporal element of the circuit in order to determine when the microRNA expression notably marks the shift from a fibroblast to a neuron.

Through SuperUROP, I'm excited to gain experience working on a long-term research project. In addition, I'm looking forward to expanding upon past work I've done in the Galloway lab and learning more about the field of synthetic biology.