Current mRNA vaccines are typically delivered in lipid nanoparticles (LNPs), which require cold-chain storage and often need multiple doses because mRNA is rapidly degraded in the body. This project aims to develop a thermally stable, single-dose mRNA vaccine platform by combining microfluidically fabricated microparticles with microneedle patches. Using microfluidics, I will generate uniform polymeric microparticles encapsulating mRNA-loaded LNPs to protect the cargo and enable controlled release over time, mimicking multiple booster doses from a single administration. The microparticles will then be incorporated into dissolvable microneedle patches for painless, needle-free delivery. By formulating the system in a dry state with stabilizing excipients, this platform aims to improve room-temperature stability while simplifying vaccine administration and distribution, particularly in resource-limited settings.

I am participating in SuperUROP because I want to develop greater independence as a researcher while contributing to the development of more accessible mRNA therapeutics. Through this project, I hope to strengthen my experimental design and scientific problem-solving skills by taking ownership of a long-term research project. I am excited to build on my previous experience with mRNA delivery systems and contribute to efforts to improve the stability and accessibility of mRNA vaccines for patients around the world.