
Jason Christopher Wang
Engineering Immunogen Trafficking in Immune Cells
2025–2026
Biological Engineering; Management
- Biological Engineering
- Health and Life Sciences
Bryson, Bryan
To enhance antigen presentation and CD4 T-cell priming, this project aims to engineer transferrin-receptor (TfR) lysosome-targeting chimeras that deliver the M. tuberculosis immunogen Ag85B into the endo-lysosomal pathway. Constructs will fuse EsxG to either a TfR-binding module or a designed EndoTag, then be benchmarked against EsxG alone for lysosomal trafficking and MHC-II presentation. This work aims to establish a modular strategy for programming immunogen trafficking in immune cells and a next-gen TB vaccine platform.
I’m joining SuperUROP for the mentored research experience paired with training in communication. My work in the Bryson lab for the past two years, as well as my industry R&D internship, has prepared me for this project. I hope to deepen my abilities as a scientist in experimental design, writing, and presentation. I’m excited to translate immune engineering ideas into a testable vaccine strategy.