Lee  Chen

Lee Chen

Scholar Title

Eric and Wendy Schmidt Center Funded Research and Innovation Scholar

Research Title

Understanding Gene Expression Dynamics of Brain Aging and Neurodegeneration

Cohort

2024–2025

Department

Electrical Engineering and Computer Science

Research Areas
  • AI for Healthcare and Life Sciences
Supervisor

Manolis Kellis

Abstract

Aging is understood as a risk factor for many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Using single-cell sequencing methods, we’re able to investigate the gene expression and accessibility of brain neurons in individuals across different ages. This allows us to understand the changes in how cell types communicate with each other, repair their own genetic material, and move through their environment. We hope to reveal the nature of cellular brain aging and offer possible points of therapeutic intervention.

Quote

I am participating in SuperUROP to gain experience in carrying out an independent project. I have worked with similar datasets and enjoyed the explorative nature of bioinformatics research. I’m excited to explore the effects of aging on the brain.

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